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Osteoarthritis, also called degenerative joint disease, is caused by inflammation, breakdown and an eventual loss of the cartilage of the joints. This damage to the joint cartilage leads to the rubbing of bone surfaces producing pain and difficulty in movement.

A Degenerative joint disease most commonly affects middle-aged and elderly populations as well as individuals with a history of musculoskeletal trauma often suffered from automobile accidents and sports-related injuries. It generally affects weight-bearing joints, such as knees, hips, feet, and spine. Women are generally more affected than men.